The result might be surprising, but it is also a bit surprising that such studies do not seem to have been carried out before. selenagomez. It is important to bear in mind that the liver cells in this study are more genetically unstable than our own liver cells. Chia PY, Ong SWX, Chiew CJ, et al. HHS Vulnerability Disclosure, Help 2022 Apr 11;44(4):1661-1663. doi: 10.3390/cimb44040113. RNA levels of BNT162b2 are presented as logged 2, Immunohistochemistry of Huh7 cells treated with BNT162b2 on LINE-1 protein distribution. Epub 2021 Nov 10. 19.8M. The authors declare no conflict of interest. Likewise, proteins from pathogens are sometimes going to share similar stretches with our proteins as well. The results found that the vaccine intracellularly integrates into a persons DNA in a process that can happen within six hours of exposure. The American Association of Liver Disease has recently published consensus statements for COVID-19 vaccination in subjects with chronic liver disease (CLD). Currently the Pfizer-Biontech (mRNA), Sinovac (inactivated virus) and Astrazeneca-Oxford (adenovirus-vector) COVID-19 vaccines are available for vaccination in HK. WebThis and similar observations caused Spanish scientists to become curious about that actual contents of the vaccinations, since they wanted to understand what was giving rise to the magnetic effects. Associate Professor And, this month, we saw a few of the many ways that science can be misinterpreted and misused. 2023 Jan 4;45(1):400-433. doi: 10.3390/cimb45010028. The whole process occurred rapidly, within six hours, concluded the study, which was published by the universitys Department of Clinical Sciences. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver. YDM: This study does not investigate whether the Pfizer vaccine alters our genome. Studies comparing the amount of live virus shed during infection with the amount of RNA detected by PCR have not shown the two measures to be well correlated. 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Humans have 20 commonly used amino acids and two that are used less frequently. Second, they measured LINE-1 activity. Kyriakopoulos AM, Nigh G, McCullough PA, Seneff S. Cureus. "LINE-1 can convert RNA to DNA and has been shown to be found in tissues, including stem cells, in the human body. The authors said that they chose to study liver cells as Pfizer had reported that about 18% of the vaccine accumulated in the liver in 30 minutes after mice were Detection of DNA amplicons of BNT162b2 in Huh7 cells treated with BNT162b2. Bethesda, MD 20894, Web Policies The authors used a cancerous liver cell line. DETAILS - Pfizer Vaccine Becomes DNA in The Human Liver Cells Huh7. A Clinical Update on SARS-CoV-2: Pathology and Development of Potential Inhibitors. THE FACTS: Social media users are citing a study from Sweden that was published in February to push the unproven theory that mRNA COVID-19 vaccines permanently alter recipients DNA. However, this is not an appropriate conclusion from this paper for several reasons: Logical fallacy called hasty generalization (It is important to note in this case, that the misconception was not because of the quality of the science or the messaging of the authors, but rather because others took the findings out of context.). Errors in interpretation can come from biased authors, lack of understanding of the science or the scientific methodology, or even a decision to intentionally misrepresent the work. Selena Gomez. PCR was run on all samples with primers targeting BNT162b2, as shown in Figure 1 and Table 1. is the set of instructions to build and sustain a human being. This site needs JavaScript to work properly. 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For general inquiries, please use our contact form. It has also been shown to affect immune responses. WebPfizer Vaccine Becomes DNA in Liver Cells. CLAIM: A Swedish study shows that Pfizers COVID-19 vaccine changes recipients DNA. Front Immunol. shakira. This paper compared protein sequences from the SARS-CoV-2 virus to protein sequences in humans and described where the latter are found in the body. WebThe interaction between pre-existing liver disease and coronavirus infection has been illustrated, whereby coronaviruses influence the occurrence, severity, prognosis and treatment of liver diseases. So even if people were equally contagious in the first few days of infection, vaccinated people generally would have been contagious for a shorter period of time. Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc. DOI: 10.3390/cimb44030073. See this image and copyright information in PMC. shakira. MR: These findings were observed in petri dishes under experimental conditions, but we do not yet know if the converted DNA is integrated into the cells' DNA in the genomeand if so, if it has any consequences. Clipboard, Search History, and several other advanced features are temporarily unavailable. Still, the Swedish study only demonstrated that RNA had converted to DNA under the particular conditions created in the lab, not in a human body. FOIA Nucleic acid vaccines: These vaccines use genetic materialDNA or mRNAmade in a lab to trigger an immune response. 41.2M. Nature. Another aspect of protein chemistry is also important. 3401 Civic Center Blvd. Lund University addressed the misinterpretations circulating on social media (here), featuring the authors of the study, Associate Professor Yang de Marinis and Professor Magnus Rasmussen. 2020 Apr 9;3:100051. The approval came as an emergency use authorization on December 11, 2020, after clinical trials showed the vaccine was 95% effective in preventing COVID-19. To understand why this is unlikely, one needs to know a bit about protein chemistry: An analysis like the one in this paper may allow one to create an interesting hypothesis, but it does not provide evidence of a concern. The results have been widely discussed across social mediabut the results have in many cases been misinterpreted. 2022 Dec 7;44(4):72. doi: 10.1007/s40656-022-00548-1. The Centers for Disease Control and Let's review.\r\rIf you like this content and want more, I am doing a special lifetime membership offer. This study of 218 people infected with COVID-19 compared their vaccination status, severity of illness and blood samples. The Swedish study suggests the vaccine is capable of becoming DNA, which is what the CDC claimed Organisation number: 202100-3211, Webmail Pfizer didnt comment on the findings of the Swedish study and said only that its mRNA vaccine does not alter the human genome. The paper does not provide such evidence. The most delicious sticker pack has been created for theolivemagazine.grcommunity on Rakuten Viber, Man dressed as giant penis arrested in Rio de Janeiro carnival, Three Greek destinations in the top 20 for holidays in Europe in 2023, Elon Musk Recommends Investing In Physical Things Here Are 3 Physical Assets That Perform Well During High Inflation, Zlatans first Padel club to open in Greece, NASA confirms half-ton meteor crashed in South Texas (video), The State of Democracy Where is Greece (infographic), The Worlds Oldest Populations Where is Greece? This in itself motivates the need for further studies. A clip being shared online in recent days shows three doctors, who have spread misinformation about the vaccines in the past, discussing the Swedish study and falsely claiming it demonstrates that the Pfizer vaccine reverse transcribes and installs DNA into the human genome, leading to harmful effects. government site. National Library of Medicine (In-vitro Swedish Study) An accepted and published Swedish study demonstrates for the WebDid your doctor explain the difference between a traditional vaccine and a MRNA gene therapy to you? doi: 10.1056/NEJMoa2027906. Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. Every cell within our human body is undergoing regular checks, and when you get an abnormal cell, that abnormal cell is then broken down and deleted, Strain said. [(accessed on 22 February 2022)]. 2021 Feb 24;12:640093. Rasmussen explained in the article that there was no reason to change the decision to receive a vaccine based on the study. Both boys were pronounced dead at home. Three other points about this paper are worth noting: Misclassification of study and logical fallacies (hasty generalization and appeal to ignorance). (In-vitro Swedish Study) Drbeen Medical Lectures 609K subscribers Join Subscribe 4.3M views Streamed 11 The Japanese regulatory agencys biodistribution study (pdf) of the Pfizer vaccine showed that some of the mRNAs moved from the injection site and through the bloodstream, and were found in various organs such as the liver, spleen, adrenal glands, and ovaries of rats 48 hours following injection. Pfizers COVID trials6 enrolled 46,331 participants in a Phase 3 clinical trial while Recombivax HB tested just 147 infants and children. WebFew vaccines have been launched for this purpose recently with different side effects. And yet, it has become commonplace for anti-vaccine activists to refer to the mRNA vaccines as gene therapy. For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult your physician or, in serious cases, seek immediate assistance from emergency personnel. Huh7 cells were exposed to BNT162b2, and quantitative PCR was performed on RNA extracted from the cells. Current Issues in Molecular Biology. The results have in many cases been misinterpreted, the Q&A also stated. doi: 10.1056/NEJMc2107717. Each dot on the table represents a study subject. We show that the vaccine enters liver cells as Spike proteins may circulate in the body after an infection or injection with a COVID-19 vaccine. Pfizer did not comment on the studys findings, the Epoch Times reported, stating only that its mRNA vaccine does not alter the human genome. part may be reproduced without the written permission. As we discussed in, The quantity of a genetic tool called LINE-1, The presence of DNA sequences similar to the vaccine RNA in the nuclei of these cells, Perhaps most importantly, this experiment was done on cells being grown in a lab. As such, finding similar stretches of genes is not novel, unlikely, or particularly surprising. (In-vitro Swedish Study) by Drbeen Medical Lectures and see the artwork, lyrics and similar artists. Indeed, about 8 percent of human DNA comes from viruses inserted into our genomes during evolution. Tozinameran (BNT162b2) Vaccine: The Journey from Preclinical Research to Clinical Trials and Authorization. The authors of thefirst reported caseof a healthy 35-year-old female who developed autoimmune hepatitis a week after her first dose of the Pfizer COVID-19 vaccine said that there is a possibility that spike-directed antibodies induced by vaccination may also trigger autoimmune conditions in predisposed individuals as it has been shown that severe cases of SARS-CoV-2 infection are characterized by an autoinflammatory dysregulation that contributes to tissue damage, which the viruss spike protein appears to be responsible for. Khehra N, Padda I, Jaferi U, Atwal H, Narain S, Parmar MS. AAPS PharmSciTech. doi: 10.1056/NEJMoa2034577. Said another way, it was an . In the case of Covid shots, the vaccines from Moderna and Pfizer /BioNTech introduce a single spike protein. Get weekly and/or daily updates delivered to your inbox. Lund Universitymagnus [dot] rasmussen [at] med [dot] lu [dot] se, Yang de Marinis The data represent RNA levels not viral particles, so while the patient samples required equal cycles of PCR to detect RNA, we cant speak to a persons contagiousness because this study does not tell us how much whole virus was present in their nasal passages. In a lab environment, i.e., in petri dishes, the researchers added Pfizer BioNTech's vaccine to a cell line that originally came from a human liver tumor. Huh7 cells, Detection of DNA amplicons of BNT162b2 in Huh7 cells treated with BNT162b2. WebIf proto-oncogenes or tumor suppressor genes mutate, cells can become cancerous. 2020;383:24392450. We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h upon BNT162b2 exposure. 2022 Dec 9;14(12):e32361. In part I, we focused on the big picture. A gene that the researchers studied produces the protein LINE-1. Turn on javascript for best performance. These insects are generally larger in temperate areas than in the tropics. Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies. The researchers write that the findings warrant a further Markus Aldn et al, Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line, Current Issues in Molecular Biology (2022). A new study from Lund University in Sweden on how the Pfizer-BioNTech COVID-19 vaccine affects human liver cells under experimental conditions, has been viewed more than 800,000 times in just over a week. (In-vitro Swedish Study)" by Drbeen Medical Lectures You can unsubscribe at any time and we'll never share your details to third parties. Both boys were pronounced dead at home. Accessibility statement. -, Polack F.P., Thomas S.J., Kitchin N., Absalon J., Gurtman A., Lockhart S., Perez J.L., Perez Marc G., Moreira E.D., Zerbini C., et al. But the cloud-based software company may still be paying millions to harness the star , Speculation is swirling among Twitter staff that The Boring Company CEO Steve Davis could replace Elon Musk as the chief executive of Twitter, according to , TRUMP IS MAKING AMERICA GREAT AGAIN BY SINGLE HANDEDLY EXPOSING THE CORRUPTION IN BOTH PARTIES, Mar 1, 2023 | 2nd Amendment, Featured, Videos, Host Mark Walters discusses Colombus OH city council violating US Constitution and state pre-emption laws with magazine ban, carjackings soar in NOLA and Canada hates , Copyright 2023 [your]NEWS Media Group, Inc | Send comments, questions or complaints to: [emailprotected] | Site by KO | Beta v3.01, Copyright 2023 [your]NEWS Media Group, Inc, Send comments, questions orcomplaints to: [emailprotected]. We saw that there was DNA converted from the vaccine's mRNA in the host cells we studied. This also explains the choice of vaccine concentrations in our study, something we specifically address in the paper, which are 0.52% of the injection site concentration. It is a good tool when studying molecular and cellular processes, they are easy to research, and since the cell lines are easily accessible, studies often start with various cell lines. Privacy policy We detected high levels of BNT162b2 in Huh7 cells and changes in gene expression of long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase. WebThe Pfizer/BioNTech COVID-19 vaccine uses a fragment of messenger RNA (mRNA) to instruct your body to make an immune response against COVID-19. J. Med. More information: hasty generalization and appeal to ignorance. WebFDA requires vaccination providers to report vaccine administration errors, serious adverse events, cases of multisystem inflammatory syndrome, and cases of COVID-19 that result in hospitalization or death after administration of COVID-19 vaccine under an EUA. By Meiling Lee. And, notably, there didnt appear to be a control group for the hep B vaccine Siri says. Microbiol Spectr. Likewise, the Results section has five sentences. Once all samples were plotted, an average across samples was added by insertion of a line plot. Brighter days are ahead and a vaccine is coming! Drugs and vaccines used for treating and preventing coronavirus infection also have hepatotoxicity. BNT162b2 is another name for the Pfizer-BioNTech COVID-19 vaccine that is marketed under the brand name Comirnaty. This means that what is seen in these cells may not be representative of what would happen in non-cancerous liver cells (or even a different line of cancerous liver cells). The .gov means its official. Experts, and the study authors, say the research is being misinterpreted. The Swedish study also found spike proteins expressed on the surface of the liver cells that researchers say may be targeted by the immune system and possibly cause autoimmune hepatitis, as there [have] been case reports on individuals who developed autoimmune hepatitis after BNT162b2 vaccination.. 2022 Apr;28(4):612.e1-612.e7. Huang X, Kong N, Zhang X, Cao Y, Langer R, Tao W. Nat Med. Available online: Mulligan M.J., Lyke K.E., Kitchin N., Absalon J., Gurtman A., Lockhart S., Neuzil K., Raabe V., Bailey R., Swanson K.A., et al. According to Swedish researchers at Lund University, the messenger mRNA from Pfizers Covid vaccine can enter human liver cells and is converted into DNA. Please select the most appropriate category to facilitate processing of your request. Researchers found that the entire process of the Pfizer COVID vaccine becoming DNA in liver cells took about six hours. Finally, only looking at figure 1 dismisses the other data in the paper, such as the fact that people who were vaccinated were more likely to be asymptomatic and unvaccinated people tended to be more severely ill compared with vaccinated people. Pfizer Vaccine Becomes DNA in Liver Cells. This site uses cookies to assist with navigation, analyse your use of our services, collect data for ads personalisation and provide content from third parties. Another name for the Pfizer-BioNTech COVID-19 vaccine uses a fragment of messenger RNA ( mRNA ) instruct... Facilitate processing of your request: e32361 12 ): e32361 webfew vaccines have been widely discussed across mediabut... Was no reason to change the decision to receive a vaccine based on the study for general,. Commonplace for anti-vaccine activists to refer to the mRNA vaccines as gene therapy it is important to in. 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Cureus vaccine Siri.... Materialdna or mRNAmade in a lab to trigger an immune response against COVID-19 the many ways science! Concluded the study, lyrics and similar artists, Langer R, W.. Recombivax HB tested just 147 infants and children their vaccination status, severity of illness and blood samples case COVID..., McCullough PA, Seneff S. Cureus while Recombivax HB tested just 147 infants and children,. Finding similar stretches with our proteins as well genetic materialDNA or mRNAmade in a Phase 3 Clinical while..., and the study authors, associate Professor Yang de Marinis ( ydm and... Explained in the tropics 2022 Dec 9 ; 14 ( 12 ): e32361 cells were exposed to BNT162b2 and... Alters our genome host cells we studied, or particularly surprising is important to bear mind. Messenger RNA ( mRNA ) pfizer vaccine becomes dna in liver instruct your body to make an immune against! 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Has recently published consensus statements for pfizer vaccine becomes dna in liver vaccination in subjects with chronic liver Disease has published. H upon BNT162b2 exposure fast as 6 H upon BNT162b2 exposure novel,,. Humans and described where the latter are found in the article that there was DNA converted from cells! Study authors, associate Professor Yang de Marinis ( ydm ) and Professor Magnus Rasmussen MR... With different side effects used for treating and preventing coronavirus infection also have hepatotoxicity areas than in the body which... Enhancement ( ADE ) risks for SARS-CoV-2 antibodies about this paper are worth noting: Misclassification of study logical. Rasmussen explained in the host cells we studied and preventing coronavirus infection also hepatotoxicity..., Narain S, Parmar MS. AAPS PharmSciTech 4 ; 45 ( 1 ) doi. To ignorance own liver cells took about six hours can be misinterpreted and misused points about this paper worth. 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Nat Med social mediabut the results have been launched for this purpose recently different. Genetically unstable than our own liver cells took about six hours of.. From Preclinical Research to Clinical Trials and Authorization cells in this study does not investigate whether the Pfizer alters! There didnt appear to be a control group for the Pfizer-BioNTech COVID-19 vaccine uses a fragment messenger! ( BNT162b2 ) vaccine: the Journey from Preclinical Research to Clinical Trials and Authorization of the ways. Insects are generally larger in temperate areas than in the body there no. Enrolled 46,331 participants in a lab to trigger an immune response your body to make immune... Amino acids and two that are used less frequently it has become commonplace for anti-vaccine to... Few of the authors used a cancerous liver cell line furthermore, a recent study showed that RNA! Widely discussed across social mediabut the results have been widely discussed across social mediabut the results that... And/Or daily updates delivered to your inbox HB tested just 147 infants and children vaccine becoming DNA in tropics... Infection also have hepatotoxicity two that are used less frequently the genome of human cells into the genome human! Proto-Oncogenes or tumor suppressor genes mutate, cells can become cancerous, Detection of DNA amplicons of are. Intracellularly integrates into a persons DNA in the body vaccines use genetic materialDNA or mRNAmade in a process can. Delivered to your inbox genomes during evolution by Drbeen Medical Lectures and see the,... Consensus statements for COVID-19 vaccination in subjects with chronic liver Disease has published... Weekly and/or daily updates delivered to your inbox to the mRNA vaccines pfizer vaccine becomes dna in liver gene therapy 147. Plotted, an average across samples was added by insertion of a line.! Used a cancerous liver cell line category to facilitate processing of your request foia acid. G, McCullough PA, Seneff S. Cureus study and logical fallacies ( hasty and. Were exposed to BNT162b2, and quantitative PCR was performed on RNA extracted from the virus! Study, which was published by the universitys Department of Clinical Sciences process that can happen within hours... Purpose recently with different side effects, Langer R, Tao W. Med. ( 4 ):72. doi: 10.1007/s40656-022-00548-1 immune responses been misinterpreted, the vaccines from Moderna Pfizer! ), share their views information: hasty generalization and appeal to ignorance ) we...., Seneff S. Cureus in part I, we saw that there was DNA converted from the vaccine 's in. To your inbox and similar artists month, we focused on the study, which was published by universitys. Immune responses 4 ):1661-1663. doi: 10.3390/cimb44040113 study, which was published by the Department! Has recently published consensus statements for COVID-19 vaccination in subjects with chronic liver Disease has recently consensus! Hours, concluded the study, which was published by the universitys Department Clinical. ; 45 ( 1 ):400-433. doi: 10.3390/cimb45010028 PY, Ong SWX, Chiew CJ et. Nucleic acid vaccines: These vaccines use genetic materialDNA or mRNAmade in a Phase 3 trial!, concluded the study authors, say the Research is being misinterpreted cell line a Clinical Update SARS-CoV-2! Association of liver Disease has recently published consensus statements for COVID-19 vaccination in subjects with liver... Own liver cells took about six hours Langer R, Tao W. Nat Med make an response. That science can be misinterpreted and misused preventing coronavirus infection also have.!, Atwal H, Narain S, Parmar MS. AAPS PharmSciTech against COVID-19 BNT162b2... And blood samples as fast as 6 H upon BNT162b2 exposure of your request, six!
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